What will work best as an ergonomic mouse will depend on your needs, but the Logitech MX Vertical will do the best if you're looking for a handshake-position wireless mouse that doesn't have trouble keeping up with you throughout the workday. The Razer Viper Ultralight is a wired mouse that doesn't skimp on the features, giving you an ambidextrous, gaming quality mouse that is easy to customize with Razer's Synapse software. The uniquely shaped Logitech MX Master has flawless wireless, is easily rechargeable via USB-C, and customization and comfort for all your day-to-day needs, no matter your OS. With a 25,000 DPI sensor, weights that you can customize, and the use of the G Hub software, this mouse is worth every penny. Logitech's G series has been making big strides in gaming accessories, and the G502 is the best of the best for gaming mice. The Lightsync is a simple yet gaming quality mouse, providing five adjustable DPI settings, six programmable buttons, and a tasteful RGB touch, all for consistently less than $40. Add on a sleek look and an ergonomic shape to reduce strain, and you have the best mouse that can do it all. The Razer Pro Click can be used wired or wirelessly, and the DPI settings ensure you can use it for both gaming and productivity.